Bombard and co-workers demonstrated the cross-linking between human telomere sequence and cis-/transplatin, with several binding sites including adenines in the loop region and guanines in the external G-quartet 20. For example, cisplatin formed an intra-strand adduct on telomere sequences, which inhibited telomerase activity and, eventually induced telomere loss and tumour cell death 18, 19. Pt-DNA adducts could interfere the recognition/binding of protein factors and the downstream biological pathways to exert the anticancer therapeutic effects. Beyond non-covalent interactions with DNA, Pt(II) complexes can covalently cross-link to the purines. Among these binders, dinuclear metal complexes, due to the unique cooperative bindings of two complex components, achieved excellent selectivity for GQ structures and the reduced drug tolerance of tumour cells comparing to mononuclear metal complexes as anticancer drug candidates 15, 16, 17. So far, substantial amount of organic compounds and metal complexes have been reported with excellent stabilization on GQ mainly via π-π stacking with G-tetrads and lead to potent antitumor activity 11, 12, 13, 14.
The significant biological roles of GQ attracted great interests to design GQ-targeting molecules for cancer therapy. The formation of G-quadruplexes was proposed to either regulate the oncogene expression or inhibit the telomerase activity 8, 9, 10. GQ was folded by the G-rich sequences from human telomeres that located at the terminal of chromosomes, as well as the promotor regions of many oncogenes, such as c-myc, c-kit and bcl2 5, 6, 7. Stacking of more than two layers of G-tetrads provided guanine quadruplexes (GQ) 1, 2, 3, 4.
G FORCE PLATINUM SOFTWARE
[ Disclaimer: Geek News Central was given a free license to review the above software package, the application was run and tested on a average PC, and was evaluated with no expectation from the software vendor of a positive review.Guanine-rich DNA sequences are prone to self-assemble into several layers of planar G-tetrad by Hoogsteen hydrogen bonds in the presence of cations, such as sodium and potassium ion. SoundSpectrum G-Force Platinum is a great value at $30.00 You can tell these folks are very serious about creating amazing visualizers for your viewing pleasure. The only thing I think is missing is a option to force a change in visualization automatically. You don’t have to be playing music as it also comes with a screen saver application that I think I will probably use more than the music portion.
The software also allows you to change effects on the fly from a innovative control board along with having a screen capture function that let’s you change your desktop background to the captured image. I am not sure what the total combinations of effects are, but it has to number several hundred. Either I have been living in a cave for a while or the folks that created this have been working overtime. We all have seen visualizers that essentially present you with dazzling colors but I was not expecting this. I loaded the application on my desktop PC, which has a 21 inch screen and a mid range video card, and ran it through iTunes and Winamp, when I enabled it I was pretty surprised. Given the opportunity to review a visualizer program I figured the kids would end up with something to look at when they were dancing downstairs turns out I will be buying a second copy. There are very few times that when I am in front of my computer that I am not working, but the kids love to play music via a older laptop that I have hooked up to my stereo system.
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